Novel pathway of insulin signaling involving Stat1alpha in Hep3B cells.

@article{Chuang1997NovelPO,
  title={Novel pathway of insulin signaling involving Stat1alpha in Hep3B cells.},
  author={Lee-Ming Chuang and Ping Wang and Heung Moon Chang and Simon C. Lee},
  journal={Biochemical and biophysical research communications},
  year={1997},
  volume={235 2},
  pages={317-20}
}
STAT proteins are important transcription factors that regulate cell growth and differentiation. To elucidate the molecular mechanisms of insulin actions, we have studied how insulin activates STAT proteins in Hep3B cells. Insulin rapidly phosphorylated Stat1alpha at tyrosine residues and increased its specific binding activities to a GAS/ISRE consensus oligonucleotide. IL-4 also phosphorylated Stat1alpha and increased DNA binding activities to the same Stat1alpha responsive element. There was… CONTINUE READING