Novel pathogenesis: regulation of apoptosis by Apelin/APJ system.

@article{Liu2017NovelPR,
  title={Novel pathogenesis: regulation of apoptosis by Apelin/APJ system.},
  author={Jiaqi Liu and Meiqing Liu and Linxi Chen},
  journal={Acta biochimica et biophysica Sinica},
  year={2017},
  volume={49 6},
  pages={
          471-478
        }
}
Apelin is the endogenous peptide APJ receptor, while APJ is a member of the G protein-coupled receptors family. Recent evidence strongly suggests that Apelin/APJ system influences apoptosis in various diseases through different signal pathways. In this review, we discuss the possible mechanisms by which the Apelin/APJ system inhibits apoptosis, including the phosphatidylinositol-3-kinase (PI3K)/Akt, ERK1/2, caspase signaling, and autophagy pathway. We also summarize the role of Apelin/APJ… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 88 REFERENCES

Immunohistochemical study of apelin, the natural ligand of receptor APJ, in a case of AIDS-related cachexia

V Esposito, M De Falco, +4 authors V Montesarchio
  • In Vivo
  • 2002
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL