Novel paraoxonase (PON1) nonsense and missense mutations predicted by functional genomic assay of PON1 status.

@article{Jarvik2003NovelP,
  title={Novel paraoxonase (PON1) nonsense and missense mutations predicted by functional genomic assay of PON1 status.},
  author={Gail P. Jarvik and Rachel L Jampsa and Rebecca J. Richter and Christopher S Carlson and Mark J. Rieder and Deborah A. Nickerson and Clement E. Furlong},
  journal={Pharmacogenetics},
  year={2003},
  volume={13 5},
  pages={
          291-5
        }
}
Paraoxonase (PON1) has been termed an environmental response enzyme for its function in the detoxification of organophosphate pesticides, nerve agents and pharmaceuticals such as glucocorticoids and statins, as well as its cardioprotective role in breaking down oxidized LDL. PON1(192) genotype can be predicted with high accuracy from an examination of the two-dimensional plot of paraoxon and diazoxon hydrolysis rates [ 1]. Individuals for whom this functional genomic assay failed to predict… CONTINUE READING
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