Novel pH-sensitive liposomes: liposomes bearing a poly(ethylene glycol) derivative with carboxyl groups.

@article{Kono1994NovelPL,
  title={Novel pH-sensitive liposomes: liposomes bearing a poly(ethylene glycol) derivative with carboxyl groups.},
  author={Koichi Kono and K Zenitani and Toru Takagishi},
  journal={Biochimica et biophysica acta},
  year={1994},
  volume={1193 1},
  pages={1-9}
}
Three kinds of succinylated poly(glycidol)s were synthesized as poly(ethylene glycol) derivatives having carboxyl groups by the reaction of poly(glycidol) with varying amounts of succinic anhydride in dimethylformamide. These polymers promoted fusion of egg-yolk phosphatidylcholine liposome more intensively with decreasing content of carboxyl groups at pH 7.4, although the extent of fusion was limited. However, the polymer with 56% of succinylated residues induced fusion of the liposome much… CONTINUE READING

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