Novel oral contraceptive for heavy menstrual bleeding: estradiol valerate and dienogest

@article{Rafie2013NovelOC,
  title={Novel oral contraceptive for heavy menstrual bleeding: estradiol valerate and dienogest},
  author={Sally Rafie and Laura M Borgelt and Erin R Koepf and Mary E Temple-Cooper and Katherine Joy Lehman},
  journal={International Journal of Women's Health},
  year={2013},
  volume={5},
  pages={313 - 321}
}
Abnormal uterine bleeding (AUB) is associated with significant direct medical costs and impacts both society and the quality of life for individual women. Heavy menstrual bleeding, a subset of AUB, also referred to as menorrhagia, is defined as menstrual blood loss greater than 80 mL or the patient’s perception of excessive blood loss. The newest treatment option available is a novel combination oral contraceptive product containing estradiol valerate (E2V) and dienogest (DNG). As with other… Expand
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References

SHOWING 1-10 OF 49 REFERENCES
Progesterone/progestogen releasing intrauterine systems versus either placebo or any other medication for heavy menstrual bleeding.
TLDR
The primary outcome was reduction in menstrual blood loss but incidence of side effects, changes in quality of life and satisfaction and acceptability measures were also assessed. Expand
Progesterone or progestogen-releasing intrauterine systems for heavy menstrual bleeding.
TLDR
The effectiveness and acceptability of progesterone or progestogen-releasing intrauterine devices in achieving a reduction in heavy menstrual bleeding is determined and Progestasert has been compared to a number of different medical therapies in one small study. Expand
Normalization of blood loss in women with heavy menstrual bleeding treated with an oral contraceptive containing estradiol valerate/dienogest.
TLDR
E₂V/DNG is highly effective for the treatment of HMB and is associated with a high rate of treatment success, according to a pooled analysis of data from two identically designed randomized, placebo-controlled, multiple center studies conducted in Europe, Australia and North America. Expand
Effective Treatment of Heavy Menstrual Bleeding With Estradiol Valerate and Dienogest: A Randomized Controlled Trial
TLDR
Oral E2 valerate and dienogest was highly effective compared with placebo in the treatment of women with heavy menstrual bleeding, prolonged menstrual bleed, or heavy and prolonged menstrual bleeding without organic pathology. Expand
Review of clinical experience with estradiol in combined oral contraceptives.
TLDR
More recent studies employing endometrial-focused progestins, e.g., DNG, and multiphasic dosing regimens appear to be a promising approach for an E2-based COC that provides efficient ovulation inhibition and acceptable cycle control. Expand
Effective treatment of heavy and/or prolonged menstrual bleeding with an oral contraceptive containing estradiol valerate and dienogest: a randomized, double-blind Phase III trial.
TLDR
E(2)V/DNG is an effective treatment in women with heavy and/or prolonged menstrual bleeding without organic pathology and a return to 'menstrual normality' during a 90-day efficacy phase. Expand
Estradiol valerate and dienogest: a new approach to oral contraception
TLDR
Estradiol valerate plus dienogest (E2V/DNG) is now available in a four-phasic regimen that integrates an estrogen stepdown and progestin stepup dosing approach along with a short two-day hormone-free interval. Expand
Nonsteroidal anti-inflammatory drugs for heavy menstrual bleeding.
TLDR
NSAIDs were more effective than placebo at reducing heavy menstrual bleeding but less effective than either tranexamic acid or danazol, although these results were based on very small studies. Expand
Bleeding pattern and cycle control with an estradiol-based oral contraceptive: a seven-cycle, randomized comparative trial of estradiol valerate/dienogest and ethinyl estradiol/levonorgestrel.
TLDR
A novel OC composed of E2V/DNG is associated with an acceptable bleeding profile that is comparable to that of an EE-containing OC. Expand
Estradiol valerate/dienogest: a novel combined oral contraceptive.
TLDR
Estradiol valerate/dienogest is a new contraceptive formulation that offers efficacy, tolerability, and an acceptable safety profile with a potentially better bleeding pattern than levonorgestrel-containing COCs. Expand
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