Novel opioid antagonists for opioid-induced bowel dysfunction and postoperative ileus.

@article{Becker2009NovelOA,
  title={Novel opioid antagonists for opioid-induced bowel dysfunction and postoperative ileus.},
  author={Gerhild Becker and H. E. Blum},
  journal={Lancet},
  year={2009},
  volume={373 9670},
  pages={1198-206}
}
Peripherally acting mu-opioid receptor antagonists methylnaltrexone and alvimopan are a new class of drugs designed to reverse opioid-induced side-effects on the gastrointestinal system without compromising pain relief. This article gives an overview of the pharmacology, the efficacy, and adverse effects of these drugs. Both compounds seem to be generally well tolerated and effective for the treatment of opioid-related bowel dysfunction and postoperative ileus. Methylnaltrexone recently… CONTINUE READING

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