Novel oligonucleotides containing two 3'-ends complementary to target mRNA show optimal gene-silencing activity.


Oligonucleotides are being employed for gene-silencing activity by a variety of mechanisms, including antisense, ribozyme, and siRNA. In the present studies, we designed novel oligonucleotides complementary to targeted mRNAs and studied the effect of 3'-end exposure and oligonucleotide length on gene-silencing activity. We synthesized both… (More)
DOI: 10.1021/jm200113t


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