Novel oleic acid derivatives enhance buccal permeation of didanosine

@article{Ojewole2014NovelOA,
  title={Novel oleic acid derivatives enhance buccal permeation of didanosine},
  author={E. Ojewole and Rahul S. Kalhapure and K. Akamanchi and T. Govender},
  journal={Drug Development and Industrial Pharmacy},
  year={2014},
  volume={40},
  pages={657 - 668}
}
Abstract The aim of this study was to explore the potential of novel oleic acid (OA) derivatives as buccal permeation enhancers for the delivery of didanosine (ddI). The OA derivatives, i.e. ester derivative (OA1E), the dicarboxylic acid derivative (OA1A) and the bicephalous dianionic surfactant (OA1ANa) were synthesized and their effects were compared to the parent OA. OA, OA1E, OA1A and OA1ANa at 1% w/w all showed potential for enhancing the buccal permeability of ddI with enhancement ratio… Expand
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