Novel nootropic drug sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation in olfactory bulbectomized mice

  title={Novel nootropic drug sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation in olfactory bulbectomized mice},
  author={Shigeki Moriguchi and Tomoya Tanaka and Hideaki Tagashira and Toshio Narahashi and Kohji Fukunaga},
  journal={Behavioural Brain Research},
Bacopa monnieri Ameliorates Memory Deficits in Olfactory Bulbectomized Mice: Possible Involvement of Glutamatergic and Cholinergic Systems
Results indicate that BM treatment ameliorates OBx-induced cognition dysfunction via a mechanism involving enhancement of synaptic plasticity-related signaling and BDNF transcription and protection of cholinergic systems from OBX-induced neuronal damage.
Wnt-5a prevents Aβ-induced deficits in long-term potentiation and spatial memory in rats
Memory Improvement by Yokukansankachimpihange and Atractylenolide III in the Olfactory Bulbectomized Mice
Atractylenolide III (Aen-III), one of the components of YKH, improved cognitive deficits and depression in the OBX mice and significantly restored CaMKII and CaMKIV signaling.
The olfactory bulbectomized rat as a model of depression: The hippocampal pathway
Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural Nootropic
This review is concentrated on the main pathways, namely, dopaminergic and cholinergic system, and the involvement of amyloid precursor protein and secondary messenger in improving the cognitive performance.
The Calcium/Calmodulin-Dependent Kinases II and IV as Therapeutic Targets in Neurodegenerative and Neuropsychiatric Disorders
The structure and functions of CaMKII and CaMKIV are reviewed, as well as how these kinases modulate the animals’ behavior to promote antidepressant- like, anxiolytic-like, and procognitive effects, to help in the understanding of the roles of the above kinases in the selected neurodegenerative and neuropsychiatric disorders.
Pharmacogenomics of Alzheimer's disease: novel therapeutic strategies for drug development.
Future perspectives for the global management of AD predict that genomics and proteomics may help in the search for reliable biomarkers, and the implementation of pharmacogenomic strategies will contribute to optimize drug development and therapeutics in AD and related disorders.
Unifi nootropics from the lab to the web: a story of academic (and industrial) shortcomings
  • F. Gualtieri
  • Physics
    Journal of enzyme inhibition and medicinal chemistry
  • 2016
This paper is a review of the work of the former academic group of research that identified two very potent molecules: Unifiram and Sun ifiram that for a variety of reasons were not protected by a patent.
Improving the reaction efficiency of condensation amidation of piperazine with benzoic acid based on kinetics study in microreactors
Here we developed a continuous flow microreactor system to synthesis N-benzoylpiperazine, which is an important intermediate of novel nootropic Sunifiram. And the kinetics of the condensation


Potentiation of N-Methyl-d-aspartate-Induced Currents by the Nootropic Drug Nefiracetam in Rat Cortical Neurons
It was concluded that nefiracetam potentiated NMDA currents through interactions with the glycine binding site of the NMDA receptor.
A Novel Cognitive Enhancer, ZSET1446/ST101, Promotes Hippocampal Neurogenesis and Ameliorates Depressive Behavior in Olfactory Bulbectomized Mice
It is confirmed that administration with mecamylamine, a nicotinic acetylcholine receptor antagonist, inhibits ZSET1446-enhanced neurogenesis in the DG and restored decreased phosphorylation of Akt and extracellular signal-regulated kinase inThe DG of OBX mice.
d-Cycloserine enhances implicit memory in Alzheimer patients
Implicit memory performance of words repeated across trials was significantly enhanced for the patients who received 15 mg d-cycloserine compared with those who received placebo, support development of NMDA receptor-mediated glutamatergic interventions for the treatment of Alzheimer-related memory disorders.
Role of Glutamate and Glutamate Receptors in Memory Function and Alzheimer's Disease a
Several reviews have pointed out a possible central role of glutamergic neurons in the development of the The ventromedial temporal lobe including the entorhinal cortex, the hippocampus, and the amygdala are the most markedly atrophied regions in Alzheimer's disease.
Nefiracetam activation of CaM kinase II and protein kinase C mediated by NMDA and metabotropic glutamate receptors in olfactory bulbectomized mice
Nefiracetam ameliorates OBX‐induced deficits in memory‐related behaviors and impairment of LTP in the hippocampal CA1 region through activation of NMDAR and mGluR5, thereby leading to an increase in activities of CaMKIIα (Thr286) and PKCα (Ser657), respectively.