Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat.

Abstract

BACKGROUND/AIMS The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is limited by their ability to induce gastrointestinal injury. Two NSAIDs were modified by incorporation of an nitroxybutyl moiety. The short-term ulcerogenic and anti-inflammatory properties of these derivatives were compared with the native NSAIDs. METHODS Rats were given… (More)

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Cite this paper

@article{Wallace1994NovelNA, title={Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat.}, author={J. L. Wallace and B. Reuter and Claudio Cicala and Webb McKnight and Michael Grisham and Giuseppe Antonio Cirino}, journal={Gastroenterology}, year={1994}, volume={107 1}, pages={173-9} }