Novel non-acidic formulations of haloperidol complexed with beta-cyclodextrin derivatives.

@article{Loukas1997NovelNF,
  title={Novel non-acidic formulations of haloperidol complexed with beta-cyclodextrin derivatives.},
  author={Yannis L. Loukas and V Vraka and Gregory Gregoriadis},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={1997},
  volume={16 2},
  pages={263-8}
}
Haloperidol (Hal), a highly hydrophobic drug, was complexed with two beta-cyclodextrin (beta-CD) derivatives. Hal solubility was increased 20-fold in the presence of a 10-fold excess of methyl beta-CD (Me beta-CD) and 12-fold in the presence of a 10-fold excess of 2-hydroxypropyl beta-CD (HP beta-CD). The stoichiometries and stability constants of Hal-Me beta-CD (1:1 and 2345 M-1 at 27 degrees C) and Hal-HP beta-CD (1:1 and 2112 M-1 at 27 degrees C) complexes were calculated by the continuous… CONTINUE READING