Novel nikkomycin analogues: inhibitors of the fungal cell wall biosynthesis enzyme chitin synthase.

@article{Obi2000NovelNA,
  title={Novel nikkomycin analogues: inhibitors of the fungal cell wall biosynthesis enzyme chitin synthase.},
  author={Kazuki Obi and J. Uda and Kazuhiko Iwase and Osamu Sugimoto and Hidetoshi Ebisu and Akira Matsuda},
  journal={Bioorganic & medicinal chemistry letters},
  year={2000},
  volume={10 13},
  pages={1451-4}
}
A series of novel nikkomycin analogue inhibitors of the chitin synthase of fungal cell wall was synthesized and evaluated for their inhibitory activities. Among them, the compound having a phenanthrene group at the terminal amino acid was found to possess strong anti-chitin synthase activity. 

From This Paper

Topics from this paper.

Similar Papers

Loading similar papers…