Novel nicotinamide adenine dinucleotide analogues as potential anticancer agents: quest for specific inhibition of inosine monophosphate dehydrogenase.

@article{Pankiewicz1997NovelNA,
  title={Novel nicotinamide adenine dinucleotide analogues as potential anticancer agents: quest for specific inhibition of inosine monophosphate dehydrogenase.},
  author={K. Pankiewicz},
  journal={Pharmacology & therapeutics},
  year={1997},
  volume={76 1-3},
  pages={
          89-100
        }
}
  • K. Pankiewicz
  • Published 1997
  • Medicine, Chemistry
  • Pharmacology & therapeutics
  • Synthetic nicotinamide adenine dinucleotide (NAD) analogues containing 5-beta-D-ribofuranosylnicotinamide (C-NAD), 6-beta-D-ribofuranosylpicolinamide (C-PAD), 3-beta-D-ribofuranosylbenzamide (BAD), and 2-beta-D-ribofuranosylthiazole-4-carboxamide (TAD) in place of the nicotinamide riboside moiety are described and evaluated as potential inhibitors of inosine monophosphate dehydrogenase (IMPDH). TAD and BAD showed potent inhibitory activity against the enzyme in the form of pyrophosphates, as… CONTINUE READING
    23 Citations
    Vitamin B3-Based Biologically Active Compounds as Inhibitors of Human Cholinesterases
    • PDF
    The plant-type ferredoxin-NADP+ reductase/ferredoxin redox system as a possible drug target against apicomplexan human parasites.
    • 47

    References

    SHOWING 1-10 OF 64 REFERENCES
    Thiazole-4-carboxamide adenine dinucleotide (TAD). Analogues stable to phosphodiesterase hydrolysis.
    • 31