Novel neurotransmitters as natural ligands of orphan G-protein-coupled receptors.

  title={Novel neurotransmitters as natural ligands of orphan G-protein-coupled receptors.},
  author={Olivier Civelli and H P Nothacker and Yuko Saito and Zhuren Wang and S. H. Lin and Rainer K Reinscheid},
  journal={Trends in neurosciences},
  volume={24 4},
The "orphan" G-protein-coupled receptors (GPCRs) are cloned GPCRs that bind unknown ligands. Since 1995, nineteen orphan GPCRs have been used as targets to identify and isolate their natural ligands via the application of the "orphan receptor strategy". These ligands are peptides, lipids or biogenic amines, and act as transmitter molecules. One nucleotide-sugar derivative and six peptides or peptide families identified through this strategy are novel and have already enriched our understanding… CONTINUE READING

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