Novel neuroprotective mechanism of action of rasagiline is associated with its propargyl moiety: interaction of Bcl-2 family members with PKC pathway.

@article{Weinreb2005NovelNM,
  title={Novel neuroprotective mechanism of action of rasagiline is associated with its propargyl moiety: interaction of Bcl-2 family members with PKC pathway.},
  author={Orly Weinreb and Tamar Amit and Orit Bar-Am and Orly Chillag-Talmor and Moussa B. H. Youdim},
  journal={Annals of the New York Academy of Sciences},
  year={2005},
  volume={1053},
  pages={348-55}
}
Our studies have provided new insights into the biological mechanism of neuroprotection of the anti-Parkinson drug, rasagiline [N-propargyl-(1R)-aminoindan], involving the association of Bcl-2 family proteins with protein kinase C (PKC) pathway. In a model of serum withdrawal-induced apoptosis of rat pheochromocytoma PC12 cells, rasagiline and its propargyl moiety, N-propargylamine, decreased cell death via multiple neuroprotective pathways that include the stimulation of PKC phosphorylation… CONTINUE READING