Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3.

@article{Gao2007NovelNF,
  title={Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3.},
  author={Ling Gao and Jiakun Wang and Konjeti Raja Sekhar and Huiyong Yin and Nicholas F Yared and Scott N Schneider and Soumya Sasi and Timothy P. Dalton and Mark E. Anderson and Jefferson Y Chan and Jason D. Morrow and Michael L Freeman},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 4},
  pages={2529-37}
}
Consumption of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can mitigate the progression of diseases in which oxidative stress represents a common underlying biochemical process. Nrf2-regulated gene expression regulates detoxification of reactive oxygen species. EPA and DHA were subjected to an in vitro free radical oxidation process that… CONTINUE READING