Novel mutation in the alpha-tropomyosin gene and transition from hypertrophic to hypocontractile dilated cardiomyopathy.

@article{RegitzZagrosek2000NovelMI,
  title={Novel mutation in the alpha-tropomyosin gene and transition from hypertrophic to hypocontractile dilated cardiomyopathy.},
  author={Vera Regitz-Zagrosek and Jeanette Erdmann and Ernst Wellnhofer and Joseph M. Raible and Eckard Fleck},
  journal={Circulation},
  year={2000},
  volume={102 17},
  pages={
          E112-6
        }
}
Awoman born in 1960 presented at age 14 years with exertional dyspnea, sinus rhythm, and left ventricular (LV) hypertrophy as shown by ECG. Hypertrophic nonobstructive cardiomyopathy (HNCM) was diagnosed by cardiac catheterization. An outflow tract gradient at rest or exercise was excluded. An echocardiogram 5 years later showed severe septal hypertrophy (Figure 1⇓). When the patient was 30 years old, repeat right and left heart catheterization confirmed HNCM (Figure 2⇓). A biopsy showed… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 23 CITATIONS

Manual of Gynecardiology

  • Springer International Publishing
  • 2017
VIEW 9 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Roles of the nebulin and β-tropomyosin genes in nemaline myopathy

VIEW 14 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Polymorphism in tropomyosin structure and function

  • Journal of Muscle Research and Cell Motility
  • 2013
VIEW 1 EXCERPT
CITES BACKGROUND