Novel mutation in 16S rRNA associated with streptomycin dependence in Mycobacterium tuberculosis.

@article{Honor1995NovelMI,
  title={Novel mutation in 16S rRNA associated with streptomycin dependence in Mycobacterium tuberculosis.},
  author={Nadine Honor{\'e} and Gilles Marchal and Stewart T Cole},
  journal={Antimicrobial agents and chemotherapy},
  year={1995},
  volume={39 3},
  pages={769-70}
}
Molecular characterization of a streptomycin-dependent mutant of Mycobacterium tuberculosis revealed the presence of a novel mutation in the rrs gene encoding 16S rRNA. Insertion of an additional cytosine in the 530 loop of 16S rRNA, a region known to be involved in streptomycin susceptibility and resistance, was associated with streptomycin dependence. 

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Streptomycin and mycobacteria

  • N. Honoré, S. T. Cole
  • Antimicrob. Agents Chemother
  • 1994
Highly Influential
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