Novel multiresistance cfr plasmids in linezolid-resistant methicillin-resistant Staphylococcus epidermidis and vancomycin-resistant Enterococcus faecium (VRE) from a hospital outbreak: co-location of cfr and optrA in VRE

@article{Lazaris2017NovelMC,
  title={Novel multiresistance cfr plasmids in linezolid-resistant methicillin-resistant Staphylococcus epidermidis and vancomycin-resistant Enterococcus faecium (VRE) from a hospital outbreak: co-location of cfr and optrA in VRE},
  author={Alexandros Lazaris and D. Coleman and A. Kearns and B. Pichon and P. Kinnevey and M. Earls and B. Boyle and B. O’Connell and G. Brennan and A. Shore},
  journal={Journal of Antimicrobial Chemotherapy},
  year={2017},
  volume={72},
  pages={3252–3257}
}
Background Linezolid is often the drug of last resort to treat infections caused by Gram-positive cocci. Linezolid resistance can be mutational (23S rRNA or L-protein) or, less commonly, acquired [predominantly cfr, conferring resistance to phenicols, lincosamides, oxazolidinones, pleuromutilins and streptogramin A compounds (PhLOPSA) or optrA, encoding oxazolidinone and phenicol resistance]. Objectives To investigate the clonality and genetic basis of linezolid resistance in 13 linezolid… Expand
Detection of optrA-positive enterococci clinical isolates in Belgium
Linezolid and Vancomycin-Resistant Enterococcus faecium in Solid Organ Transplant Recipients: Infection Control and Antimicrobial Stewardship Using Whole Genome Sequencing.
  • L. Abbo, B. Shukla, +19 authors C. Arias
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2018
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 20 REFERENCES
Reversion to susceptibility in a linezolid-resistant clinical isolate of Staphylococcus aureus.
Co-location of the oxazolidinone resistance genes optrA and cfr on a multiresistance plasmid from Staphylococcus sciuri.
  • D. Li, Yang Wang, +7 authors J. Shen
  • Biology, Medicine
  • The Journal of antimicrobial chemotherapy
  • 2016
...
1
2
...