Novel multilocus measure of linkage disequilibrium to estimate past effective population size.

@article{Hayes2003NovelMM,
  title={Novel multilocus measure of linkage disequilibrium to estimate past effective population size.},
  author={Ben John Hayes and Peter M. Visscher and Helen Clare McPartlan and M. E. Goddard},
  journal={Genome research},
  year={2003},
  volume={13 4},
  pages={
          635-43
        }
}
Linkage disequilibrium (LD) between densely spaced, polymorphic genetic markers in humans and other species contains information about historical population size. Inferring past population size is of interest both from an evolutionary perspective (e.g., testing the "out of Africa" hypothesis of human evolution) and to improve models for mapping of disease and quantitative trait genes. We propose a novel multilocus measure of LD, the chromosome segment homozygosity (CSH). CSH is defined for a… CONTINUE READING

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