Novel multifunctional anti-Alzheimer drugs with various CNS neurotransmitter targets and neuroprotective moieties.

Abstract

Traditionally, drug design programs are focused on optimizing the specificity of lead compounds against a carefully selected drug target. Disappointingly, this approach to discover a "magic bullet" drug has not met with the expected success for CNS disorders. Transcriptomics and proteomic profiling of neurodegenerative diseases have indicated that they are… (More)

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@article{Schyf2007NovelMA, title={Novel multifunctional anti-Alzheimer drugs with various CNS neurotransmitter targets and neuroprotective moieties.}, author={Cornelis J van der Schyf and Silvia A. Mandel and Werner J Geldenhuys and Tamar Amit and Yael Avramovich and Hailin Zheng and Mati Fridkin and Shunit Gal and Orly Weinreb and Orit Bar Am and Yotam Sagi and Moussa B. H. Youdim}, journal={Current Alzheimer research}, year={2007}, volume={4 5}, pages={522-36} }