Novel monoclonal antibodies to normal and pathologically altered human TDP-43 proteins

Abstract

The RNA/DNA-binding protein, TDP-43, is the key component of ubiquitinated inclusions characteristic of amyotrophic lateral sclerosis (ALS) and the majority of frontotemporal lobar degeneration (FTLD-TDP) referred to collectively as TDP-43 proteinopathies. To further elucidate mechanisms of pathological TDP-43 processing and identify TDP-43 epitopes that… (More)
DOI: 10.1186/2051-5960-2-33

Topics

6 Figures and Tables

Cite this paper

@inproceedings{Kwong2014NovelMA, title={Novel monoclonal antibodies to normal and pathologically altered human TDP-43 proteins}, author={Linda K. Kwong and David J G Irwin and Adam K. Walker and Yan Xu and Dawn M. Riddle and John Q. Trojanowski and Virginia M.-Y. Lee}, booktitle={Acta neuropathologica communications}, year={2014} }