Novel monoclonal antibodies recognizing the active conformation of epidermal growth factor receptor.

@article{Ise2010NovelMA,
  title={Novel monoclonal antibodies recognizing the active conformation of epidermal growth factor receptor.},
  author={Nobuyuki Ise and Kazuya Omi and Kyoko Miwa and Hideo Honda and Shigeki Higashiyama and Katsutoshi Goishi},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={394 3},
  pages={685-90}
}
The precise regulation of epidermal growth factor receptor (EGFR) is crucial for its function in cellular growth control. Although many antibodies against EGFR have been developed and used to analyze its regulation and function, it is not yet easy to analyze activated EGFR specifically. Activated EGFR has been mainly detected by its phosphorylation state using anti-phospho-EGFR and anti-phosphotyrosine antibodies. In the present study, we have established novel monoclonal antibodies which… CONTINUE READING

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