Novel modulators of skeletal muscle FKBP12/calcium channel complex from Ianthella basta. Role of FKBP12 in channel gating.

@article{Mack1994NovelMO,
  title={Novel modulators of skeletal muscle FKBP12/calcium channel complex from Ianthella basta. Role of FKBP12 in channel gating.},
  author={Mathew M Mack and Tadeusz F Molinski and Edmond D Buck and Isaac N Pessah},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 37},
  pages={23236-49}
}
Macrocyclic natural products derived from bromotyrosine isolated from the sponge Ianthella basta are shown to selectively modulate the skeletal isoform of the ryanodine-sensitive sarcoplasmic reticulum calcium channel by a novel mechanism involving the FKBP12/RyR-1 complex. Bastadins 5, 7, and the newly identified isomer of bastadin 5, bastadin 19, show marked differences in potency and efficacy toward activation of the binding of [3H]ryanodine. In physiological salt, bastadin 5 (5 microM… CONTINUE READING
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