Novel modifications in the series of O-(2-phthalimidoethyl)-N-substituted thiocarbamates and their ring-opened congeners as non-nucleoside HIV-1 reverse transcriptase inhibitors.

@article{Spallarossa2009NovelMI,
  title={Novel modifications in the series of O-(2-phthalimidoethyl)-N-substituted thiocarbamates and their ring-opened congeners as non-nucleoside HIV-1 reverse transcriptase inhibitors.},
  author={Andrea Spallarossa and Sara Cesarini and Angelo Ranise and O. A. Bruno and Silvia Schenone and Paolo La Colla and Gabriella Collu and Giuseppina Sanna and Barbara Secci and Roberta Loddo},
  journal={European journal of medicinal chemistry},
  year={2009},
  volume={44 4},
  pages={1650-63}
}
The structure-activity relationships (SARs) of N-aryl-O-(2-phthalimidoethyl)thiocarbamates (C-TCs) and their imide ring-opened congeners (O-TCs) as non-nucleoside HIV-1 reverse transcriptase inhibitors were further investigated. The SAR strategy involved modifications of the N-phenyl ring followed by the hybridization of the most promising N-aryl and O-(2-phthalimidoethyl) substructures. The role of stereochemistry and tert-butyl substitution of the phthalimidoethyl moiety on activity was also… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 20 references

Biochem

A. Spallarossa, S. Cesarini, +3 authors M. Bolognesi
Biophys. Res. Commun. 365 • 2008
View 8 Excerpts
Highly Influenced

Bioorg

S. Cesarini, A. Spallarossa, +5 authors R. Loddo
Med. Chem. 16 • 2008

S

F. M. Uckun, D. Erbeck, H. Tibbles
Qazi, T.K. Venkatachalam, Arzneimittelforschung 57 • 2007

D

C. A. Shaw-Reid, B. Feuston, +5 authors M. D. Miller
Lewis, Biochemistry 44 • 2005
View 1 Excerpt

Curr

N. Sluis-Cremer, N. A. Temiz, I. Bahar
HIV Res. 2 • 2004

Chem

A. Ranise, A. Spallarossa, +8 authors J. Med
46 • 2003

Eur

J. Lindberg, S. Sigurdsson, +6 authors T. Unge
J. Biochem. 269 • 2002

Antiviral Chem

G. Campiani, M. Fabbrini, +13 authors S. Caccia
Chemother. 11 • 2000

V

A. Carocci, A. Catalano, +4 authors G. Lentini
Tortorella, Tetrahedron: Asymmetry 11 • 2000
View 2 Excerpts

Acta Crystallogr

A. T. Brunger, P. D. Adams, +11 authors G. L. Warren
D54 • 1998
View 1 Excerpt

Similar Papers

Loading similar papers…