Novel model to study virulence determinants of Escherichia coli K1.

@article{Khan2007NovelMT,
  title={Novel model to study virulence determinants of Escherichia coli K1.},
  author={Naveed Ahmed Khan and Graham John Goldsworthy},
  journal={Infection and immunity},
  year={2007},
  volume={75 12},
  pages={5735-9}
}
It is shown here for the first time that locusts can be used as a model to study Escherichia coli K1 pathogenesis. E. coli K-12 strain HB101 has very low pathogenicity to locusts and does not invade the locust brain, whereas the injection of 2 x 10(6) E. coli K1 strain RS218 (O18:K1:H7) kills almost 100% of locusts within 72 h and invades the brain within… CONTINUE READING

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