Novel mode of nitric oxide neurotransmission mediated via S‐nitroso‐cysteinyl‐glycine

  title={Novel mode of nitric oxide neurotransmission mediated via S‐nitroso‐cysteinyl‐glycine},
  author={T. Salt and H. Zhang and B. Mayer and B. Benz and K. Binns and K. Do},
  journal={European Journal of Neuroscience},
  • T. Salt, H. Zhang, +3 authors K. Do
  • Published 2000
  • Chemistry, Medicine
  • European Journal of Neuroscience
  • S‐nitroso‐cysteinyl‐glycine, a novel nitric oxide‐adduct thiol compound, can be detected in the brain (2.3 ± 0.6 pmol/mg protein), and released following stimulation of sensory afferents to the rat ventrobasal thalamus in vivo (resting conditions 17 n m; stimulation: 186 nm). Iontophoretic application of CysNOGly (20–80 nA) onto thalamic neurons in vivo resulted in enhancements of excitatory responses to either NMDA or AMPA (182 ± 13.6% and 244 ± 27.8% of control values, n = 15). CysNOGly… CONTINUE READING
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