Novel mode of action of tylophorine analogs as antitumor compounds.

Abstract

Tylophorine and its analogs are phenanthroindolizidine alkaloids, several of which have been isolated from the Tylophora genus of plants. Evaluation of (+)-S-tylophorine [DCB-3500 (NSC-717335)] and its analog DCB-3503 (NSC-716802) in the National Cancer Institute tumor screen showed a fairly uniform and potent inhibition of cell growth in all 60 cell lines… (More)

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@article{Gao2004NovelMO, title={Novel mode of action of tylophorine analogs as antitumor compounds.}, author={Wenli Gao and Wing Lam and Sanbao Zhong and Conrad Kaczmarek and David C. Baker and Yung-chi Cheng}, journal={Cancer research}, year={2004}, volume={64 2}, pages={678-88} }