Novel mimics of sialyl Lewis X: design, synthesis and biological activity of a series of 2- and 3-malonate substituted galactoconjugates.

Abstract

A series of potent inhibitors of P-selectin as potential anti-inflammatory agents is reported. These compounds are derivatives of galactocerebrosides bearing a malonate side chain in positions 2 and 3 of the galactose moiety. Based on the binding mode of sialyl Lewis X, the two acidic groups of the malonate are designed to form ionic interactions with two… (More)

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Cite this paper

@article{Marinier2001NovelMO, title={Novel mimics of sialyl Lewis X: design, synthesis and biological activity of a series of 2- and 3-malonate substituted galactoconjugates.}, author={Anne Marinier and Alain Martel and Carol Bachand and Serge Plamondon and Bruno Turmel and J P Daris and Jacques Banville and Pierre Lapointe and Claudie Ouellet and Pierre Dextraze and M. Kathryn Menard and J. J. Wright and John R. Alford and D. Lee and Peter Stanley and Xina Nair and Gordon Todderud and Kenneth M. Tramposch}, journal={Bioorganic & medicinal chemistry}, year={2001}, volume={9 6}, pages={1395-427} }