Novel microsatellite markers and single nucleotide polymorphisms refine the tylosis with oesophageal cancer (TOC) minimal region on 17q25 to 42.5 kb: sequencing does not identify the causative gene

@article{Langan2004NovelMM,
  title={Novel microsatellite markers and single nucleotide polymorphisms refine the tylosis with oesophageal cancer (TOC) minimal region on 17q25 to 42.5 kb: sequencing does not identify the causative gene},
  author={Joanne E. Langan and C. Greifinger J. D. Cole and Elisabeth J. Huckle and Shaun Byrne and Fiona E Mcronald and Lynn Rowbottom and Anthony J Ellis and Joan M. Shaw and Irene M. Leigh and David P Kelsell and Ian Dunham and John K. Field and Janet M. Risk},
  journal={Human Genetics},
  year={2004},
  volume={114},
  pages={534-540}
}
Tylosis (focal non-epidermolytic palmoplantar keratoderma) is associated with the early onset of squamous cell oesophageal cancer in three families. Linkage and haplotype analyses have previously mapped the tylosis with oesophageal cancer (TOC) locus to a 500-kb region on chromosome 17q25 that has also been implicated in sporadically occurring squamous cell oesophageal cancer. In the current study, 17 additional putative microsatellite markers were identified within this 500-kb region by using… CONTINUE READING