Novel methods for measuring cardiac autophagy in vivo.

  title={Novel methods for measuring cardiac autophagy in vivo.},
  author={Cynthia N. Perry and Shiori Kyoi and Nirmala Hariharan and Hiromitsu Takagi and Junichi Sadoshima and Roberta A Gottlieb},
  journal={Methods in enzymology},
Autophagy, a highly conserved cellular mechanism wherein various cellular components are broken down and recycled through lysosomes, occurs constitutively in the heart and may serve as a cardioprotective mechanism in some situations. It has been implicated in the development of heart failure and is up-regulated following ischemia-reperfusion injury. Autophagic flux, a measure of autophagic vesicle formation and clearance, is an important measurement in evaluating the efficacy of the pathway… CONTINUE READING


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