Novel methodology for predicting photogenotoxic risk of pharmaceutical substances based on reactive oxygen species (ROS) and DNA-binding assay.

Abstract

Drug-induced phototoxic skin responses involves photoirritation, photoallergy, and photogenotoxicity. In the present study, we attempted to develop effective analytical tools to predict the photogenotoxic potential of pharmaceutical substances on the basis of their photobiological and DNA-binding properties. Photocleavage of plasmid DNA was assessed by… (More)
DOI: 10.1002/jps.21670

Topics

Cite this paper

@article{Onoue2009NovelMF, title={Novel methodology for predicting photogenotoxic risk of pharmaceutical substances based on reactive oxygen species (ROS) and DNA-binding assay.}, author={Satomi Onoue and Yoshiki Seto and Ami Oishi and Shizuo Yamada}, journal={Journal of pharmaceutical sciences}, year={2009}, volume={98 10}, pages={3647-58} }