Novel mediators of amyloid precursor protein signaling.

  title={Novel mediators of amyloid precursor protein signaling.},
  author={Andrzej Swistowski and Qiang Zhang and Mark E Orcholski and Danielle Crippen and Cathy Vitelli and Alexei Kurakin and Dale E. Bredesen},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={29 50},
Multiple recent reports implicate amyloid precursor protein (APP) signaling in the pathogenesis of Alzheimer's disease, but the APP-dependent signaling network involved has not been defined. Here, we report a novel consensus sequence for interaction with the PDZ-1 and PDZ-2 domains of the APP-interacting proteins Mint1, Mint2, and Mint3 (X11alpha, X11beta, and X11gamma), and multiple novel interactors for these proteins, with the finding that transcriptional coactivators are highly represented… CONTINUE READING