Novel mechanisms underlying the immediate and transient global tolerization of splenic dendritic cells after vaccination with a self-antigen.

@article{Farkas2014NovelMU,
  title={Novel mechanisms underlying the immediate and transient global tolerization of splenic dendritic cells after vaccination with a self-antigen.},
  author={Adam M. Farkas and Olivera Olja J Finn},
  journal={Journal of immunology},
  year={2014},
  volume={192 2},
  pages={658-65}
}
Dendritic cells (DCs) are important orchestrators of the immune response, ensuring that immunity against pathogens is generated, whereas immunity against healthy tissues is prevented. Using the tumor Ag MUC1, we previously showed that i.v. immunization of MUC1 transgenic mice, but not wild-type, with a MUC1 peptide resulted in transient tolerization of all… CONTINUE READING