Novel mechanisms of E2F induction by BK virus large-T antigen: requirement of both the pRb-binding and the J domains.

@article{Harris1998NovelMO,
  title={Novel mechanisms of E2F induction by BK virus large-T antigen: requirement of both the pRb-binding and the J domains.},
  author={Kerry F. Harris and Joan B Christensen and Eric H. Radany and Michael J Imperiale},
  journal={Molecular and cellular biology},
  year={1998},
  volume={18 3},
  pages={1746-56}
}
E2F activity is regulated in part by the retinoblastoma family of tumor suppressor proteins. Viral oncoproteins, such as simian virus 40 (SV40) large-T antigen (TAg), adenovirus E1A, and human papillomavirus E7, can disrupt the regulation of cellular proliferation by binding to pRb family members and dissociating E2F-pRb family protein complexes. BK virus (BKV), which infects a large percentage of the human population and has been associated with a variety of human tumors, encodes a TAg… CONTINUE READING