Novel mechanisms in chemically induced hepatotoxicity.

  title={Novel mechanisms in chemically induced hepatotoxicity.},
  author={Harihara M. Mehendale and Richard A. Roth and A. Jay Gandolfi and James E Klaunig and John J. Lemasters and Lawrence R. Curtis},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={8 15},
This review focuses on cellular events that modulate hepatotoxicity subsequent to initial liver insult. Cellular events that determine the nature and extent of hepatotoxic injury and the ultimate outcome of that injury are also discussed. The roles of cell types other than hepatocytes, hepatocyte organelle-specific processes, and regeneration in progression or recovery from liver injury are emphasized. Leukocyte activities are key events in two distinct hepatotoxicities. Neutrophil-mediated… CONTINUE READING


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