Novel mechanisms in accelerated vascular calcification in renal disease patients.

@article{Demer2002NovelMI,
  title={Novel mechanisms in accelerated vascular calcification in renal disease patients.},
  author={Linda L. Demer and Yin Tintut and Farhad Parhami},
  journal={Current opinion in nephrology and hypertension},
  year={2002},
  volume={11 4},
  pages={437-43}
}
PURPOSE OF REVIEW Vascular calcification occurs more often and earlier in patients with end-stage renal disease than in normal controls. It is a regulated biological process following many of the cellular and molecular programs in osteogenesis. This review summarizes some of the regulatory mechanisms that may explain its severity in renal patients. RECENT FINDINGS A subpopulation of cells from arteries and cardiac valves produce a mineralizing matrix and undergo osteoblastic differentiation… CONTINUE READING