Novel mechanisms for estrogen-induced neuroprotection.

  title={Novel mechanisms for estrogen-induced neuroprotection.},
  author={Meharvan Singh and James A. Dykens and James William Simpkins},
  journal={Experimental biology and medicine},
  volume={231 5},
Estrogens are gonadal steroid hormones that are present in the circulation of both males and females and that can no longer be considered within the strict confines of reproductive function. In fact, the bone, the cardiovascular system, and extrahypothalamic regions of the brain are now well-established targets of estrogens. Among the numerous aspects of brain function regulated by estrogens are their effects on mood, cognitive function, and neuronal viability. Here, we review the supporting… CONTINUE READING


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