Novel mechanisms for crotonaldehyde-induced lung edema

  title={Novel mechanisms for crotonaldehyde-induced lung edema},
  author={Yue Li and Jianjun Chang and Yong Cui and Runzhen Zhao and Yan Ding and Yapeng Hou and Zhiyu Zhou and Hong-Long Ji and Hongguang Nie},
Background Crotonaldehyde is a highly noxious α,β-unsaturated aldehyde in cigarette smoke that causes edematous acute lung injury. Objective To understand how crotonaldehyde impairs lung function, we examined its effects on human epithelial sodium channels (ENaC), which are major contributors to alveolar fluid clearance. Methods We studied alveolar… CONTINUE READING