Novel mechanisms for caspase inhibition protecting cardiac function with chronic pressure overload

@article{Park2012NovelMF,
  title={Novel mechanisms for caspase inhibition protecting cardiac function with chronic pressure overload},
  author={Misun Park and Stephen F. Vatner and Lin Yan and Shumin Gao and Seunghun Yoon and Grace Jung Ah Lee and Lai-hua Xie and Richard N. Kitsis and Dorothy E. Vatner},
  journal={Basic Research in Cardiology},
  year={2012},
  volume={108},
  pages={1-13}
}
Myocyte apoptosis is considered a major mechanism in the pathogenesis of heart failure. Accordingly, manipulations that inhibit apoptosis are assumed to preserve cardiac function by maintaining myocyte numbers. We tested this assumption by examining the effects of caspase inhibition (CI) on cardiac structure and function in C57BL/6 mouse with pressure overload model induced by transverse aortic constriction (TAC). CI preserved left ventricular (LV) function following TAC compared with the… CONTINUE READING

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