Novel mechanism of reduced proliferation in ovarian clear cell carcinoma cells: cytoplasmic sequestration of CDK2 by p27.

@article{Itamochi2011NovelMO,
  title={Novel mechanism of reduced proliferation in ovarian clear cell carcinoma cells: cytoplasmic sequestration of CDK2 by p27.},
  author={Hiroaki Itamochi and Tomokazu Yoshida and Cheryl Lyn Walker and Chandra Bartholomeusz and Daisuke Aoki and Hideki Ishihara and Nao Suzuki and Junzo Kigawa and Naoki Terakawa and Naoto T Ueno},
  journal={Gynecologic oncology},
  year={2011},
  volume={122 3},
  pages={641-7}
}
OBJECTIVE Ovarian clear cell carcinoma (CCC) carries a poor prognosis because of its insensitivity to chemotherapy. We previously found an association between reduced proliferation of CCC and chemoresistance; here we investigated the mechanism of the reduced proliferation. METHODS We assessed cell cycle function by measuring the activity of cyclin-dependent kinases (CDKs) and the protein expression of cyclins, the CDK inhibitors, and p53 in 22 ovarian cancer cell lines and 60 human ovarian… CONTINUE READING
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