Novel mechanism of massive photoreceptor degeneration caused by mutations in the trp gene of Drosophila.

@article{Yoon2000NovelMO,
  title={Novel mechanism of massive photoreceptor degeneration caused by mutations in the trp gene of Drosophila.},
  author={Jaeseung Yoon and Hagit Cohen Ben-Ami and Young Seon Hong and Soyeon Park and Larkin L. Strong and John Bowman and Chaoxian Geng and Kwanghee Baek and Baruch Minke and William L. Pak},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2000},
  volume={20 2},
  pages={649-59}
}
The Drosophila trp gene encodes a light-activated Ca(2+) channel subunit, which is a prototypical member of a novel class of channel proteins. Previously identified trp mutants are all recessive, loss-of-function mutants characterized by a transient receptor potential and the total or near-total loss of functional TRP protein. Although retinal degeneration does occur in these mutants, it is relatively mild and slow in onset. We report herein a new mutant, Trp(P365), that does not display the… CONTINUE READING

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