Novel mechanism of glycopeptide resistance in the A40926 producer Nonomuraea sp. ATCC 39727.

  title={Novel mechanism of glycopeptide resistance in the A40926 producer Nonomuraea sp. ATCC 39727.},
  author={Giorgia Letizia Marcone and Fabrizio Beltrametti and Elisa Binda and L{\`u}cia Carrano and Lucy C Foulston and Andrew Hesketh and Mervyn Bibb and Flavia Marinelli},
  journal={Antimicrobial agents and chemotherapy},
  volume={54 6},
In glycopeptide-resistant enterococci and staphylococci, high-level resistance is achieved by replacing the C-terminal d-alanyl-d-alanine of lipid II with d-alanyl-d-lactate, thus reducing glycopeptide affinity for cell wall targets. Reorganization of the cell wall in these organisms is directed by the vanHAX gene cluster. Similar self-resistance mechanisms have been reported for glycopeptide-producing actinomycetes. We investigated glycopeptide resistance in Nonomuraea sp. ATCC 39727, the… CONTINUE READING


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