Novel mechanism and factor for regulation by HIV-1 Tat.

  title={Novel mechanism and factor for regulation by HIV-1 Tat.},
  author={Qiang Zhou and Phillip A. Sharp},
  journal={The EMBO journal},
  volume={14 2},
Tat regulation of human immunodeficiency virus (HIV) transcription is unique because of its specificity for an RNA target, TAR, and its ability to increase the efficiency of elongation by polymerase. A reconstituted reaction that is Tat-specific and TAR-dependent for activation of HIV transcription has been used to identify and partially purify a cellular activity that is required for trans-activation by Tat, but not by other activators. In the reaction, Tat stimulates the efficiency of… CONTINUE READING


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