Novel markers of oxidative stress in actively progressive HIV dementia

@article{Sacktor2004NovelMO,
  title={Novel markers of oxidative stress in actively progressive HIV dementia},
  author={Ned Sacktor and Norman J Haughey and Roy Cutler and Anita Tamara and Avindra Nath},
  journal={Journal of Neuroimmunology},
  year={2004},
  volume={157},
  pages={176-184}
}
Oxidative stress leads to the production of reactive oxygen species that can attack lipid membranes resulting in cellular dysfunction and death. Cellular redox state is closely linked to ceramide, sphingomyelin, and 4-hydroxynonenal (HNE) levels. We describe data showing increased levels of these oxidative stress markers in HIV encephalitis. In addition, actively progressing HIV dementia is associated with increases in HNE and ceramide, while inactive HIV dementia is associated with increases… CONTINUE READING
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