Novel macrophage polarization model: from gene expression to identification of new anti-inflammatory molecules

@article{LpezCastejn2010NovelMP,
  title={Novel macrophage polarization model: from gene expression to identification of new anti-inflammatory molecules},
  author={Gloria L{\'o}pez-Castej{\'o}n and Alberto Baroja-Mazo and Pablo Pelegr{\'i}n},
  journal={Cellular and Molecular Life Sciences},
  year={2010},
  volume={68},
  pages={3095-3107}
}
Plasticity is a well-known property of macrophages that is controlled by different changes in environmental signals. Macrophage polarization is regarded as a spectrum of activation phenotypes adjusted from one activation extreme, the classic (M1), to the other, the alternative (M2) activation. Here we show, in vitro and in vivo, that both M1 and M2 macrophage phenotypes are tightly coupled to specific patterns of gene expression. Novel M2-associated markers were characterized and identified as… CONTINUE READING
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