Novel macrocyclic C-aryl glucoside SGLT2 inhibitors as potential antidiabetic agents.

Abstract

Novel macrocyclic C-aryl glucoside SGLT2 inhibitors were designed and synthesized. Two different synthetic routes of macrocyclization were adopted to prepare novel ansa SGLT2 inhibitors. Among the compounds tested, [1,7]dioxacyclopentadecine macrocycles possessing methylthiophenyl at the distal ring 40 or ethoxyphenyl at the distal ring 23 showed the best… (More)
DOI: 10.1016/j.bmc.2011.07.045

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