Novel mRNA isoforms and mutations of uridine monophosphate synthetase and 5-fluorouracil resistance in colorectal cancer

@article{Griffith2013NovelMI,
  title={Novel mRNA isoforms and mutations of uridine monophosphate synthetase and 5-fluorouracil resistance in colorectal cancer},
  author={Malachi Griffith and Jill C. Mwenifumbo and Pak Yan Cheung and Jessica E. Paul and Trevor J. Pugh and Michelle J. Tang and Suganthi Chittaranjan and Ryan D. Morin and Jennifer K. Asano and Alla A. Ally and Li-yun Miao and A Lee and Sylvia Yat-Yee Chan and Georgia Taylor and Tesa M. Severson and Y C Hou and Obi L. Griffith and Ge Sheng Cheng and Karen L Novik and Rene{\'e} H Moore and Mandy Luk and David Owen and Catriona J. Brown and Gregg B Morin and Stanley Gill and Isabella T. Tai and Marco A. Marra},
  journal={The Pharmacogenomics Journal},
  year={2013},
  volume={13},
  pages={148-158}
}
The drug fluorouracil (5-FU) is a widely used antimetabolite chemotherapy in the treatment of colorectal cancer. The gene uridine monophosphate synthetase (UMPS) is thought to be primarily responsible for conversion of 5-FU to active anticancer metabolites in tumor cells. Mutation or aberrant expression of UMPS may contribute to 5-FU resistance during treatment. We undertook a characterization of UMPS mRNA isoform expression and sequence variation in 5-FU-resistant cell lines and drug-naive or… CONTINUE READING
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