Novel low molecular weight microtubule-associated protein-2 isoforms contain a functional nuclear localization sequence.

@article{Loveland1999NovelLM,
  title={Novel low molecular weight microtubule-associated protein-2 isoforms contain a functional nuclear localization sequence.},
  author={Kate L Loveland and Daniella Herszfeld and Boyang Chu and E Rames and E. Jennifer Christy and Lyndall J Briggs and Rushdi Shakri and David de Kretser and David Andrew Jans},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 27},
  pages={19261-8}
}
Known high and low molecular weight (LMW) MAP2 protein isoforms result from alternative splicing of the MAP2 gene. Contrary to previous reports that MAP2 is neural-specific, we recently identified MAP2 mRNA and protein in somatic and germ cells of rat testis, and showed the predominant testicular isoform is LMW. Although cytoplasmic in neural tissue, MAP2 appeared predominantly nuclear in germ cells using immunohistochemistry. We sought to determine whether this unexpected localization was due… CONTINUE READING