Novel isocyanide-based four-component reaction: a facile synthesis of fully substituted 3,4-dihydrocoumarin derivatives.

Abstract

A novel isocyanide-based four-component reaction between a 2-hydroxybenzaldehyde, Meldrum's acid, an isocyanide, and an aromatic or an aliphatic alcohol efficiently provide 3,4-dihydrocoumarin derivatives in good to excellent yields without using any catalyst or activation. The reaction can be carried out as a simple one-pot protocol at room temperature. 
DOI: 10.1021/ol800856e

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Cite this paper

@article{Shaabani2008NovelIF, title={Novel isocyanide-based four-component reaction: a facile synthesis of fully substituted 3,4-dihydrocoumarin derivatives.}, author={Ahmad Shaabani and Ebrahim Soleimani and Ali Hossein Rezayan and Afshin Sarvary and Hamid Reza Khavasi}, journal={Organic letters}, year={2008}, volume={10 12}, pages={2581-4} }